Endocrinology of the Aging Male

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Conceptual The endocrinology of the aging manly is complex, with multiple hormones all along the hypothalamic-pituitary-testicular HPT axis interacting along with one another in feedback. The consequence of these changes is wide-ranging as of the ubiquitous role of femininity hormones in male physiology. This division discusses the endocrinology of the aging male. We provide an overview of the regulation of the HPT affiliation with an emphasis on the changes that occur with aging and the measurement of gonadal steroids, including hormone pulsatility, within-subject and circadian variations. The difficulties of assessing the symptoms of late-onset hypogonadism are highlighted. There is a comprehensive discussion of the epidemiology of sex hormone changes, including their age associations, prevalence of symptomatic hypogonadism, secular changes, risk factors, and the association of sex hormones with outcomes. Introduction Aging is associated with degenerative changes in multiple organ systems. The rate and extent to which these occur depend on genetics, the apparition of other disease processes, and the accumulated effects of socioeconomic, lifestyle, after that environmental factors. Although there is denial equivalence in men of the brusque cessation of cyclical ovarian activity so as to occurs in women, a variable after that inconsistent decrease in testosterone with escalate age is observed, albeit that constant at very advanced age, sexual after that reproductive function may be within average limits.

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