Where skin cancer develops Open pop-up dialog box Close Where skin cancer develops Where skin cancer develops Skin cancer begins in the cells that make up the outer layer epidermis of your skin. One type of skin cancer called basal cell carcinoma begins in the basal cells, which make skin cells that continuously push older cells toward the surface. As new cells move upward, they become flattened squamous cells, where a skin cancer called squamous cell carcinoma can occur. Melanoma, another type of skin cancer, arises in the pigment cells melanocytes. Melanoma occurs when something goes wrong in the melanin-producing cells melanocytes that give color to your skin. Normally, skin cells develop in a controlled and orderly way — healthy new cells push older cells toward your skin's surface, where they die and eventually fall off. But when some cells develop DNA damage, new cells may begin to grow out of control and can eventually form a mass of cancerous cells. Just what damages DNA in skin cells and how this leads to melanoma isn't clear.
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